PL EN


Preferences help
enabled [disable] Abstract
Number of results
2008 | 56 | 2 | 141-145
Article title

Quantification of the CD8+ T cell response against a mucin epitope in patients with breast cancer

Content
Title variants
Languages of publication
EN
Abstracts
EN
Mucin 1, encoded by the MUC1 gene, is a tumor-associated antigen expressed on the surface of breast cancer cells. It would be of interest to see whether there is a naturally existing T cell immune response against mucin epitopes in cancer patients. Materials and Methods: Using tetramer and interferon gamma assays, the immune response to one MUC1 peptide epitope in the peripheral blood of breast cancer patients was quantified. The data were compared with the clinical course of the patients. Results: CD8+ T cells capable of recognizing the HLA-A*0201-restricted STAPPVHNV epitope were detected in 9 of 19 patients with a frequency ranging 0.01?0.082%. No significant difference was found between the occurrence of epitope-specific CD8+ T cells of patients with progressive disease and disease-free patients. However, all patients with stable disease showed a specific immune response, including both patients with the highest frequency. Conclusions: The results of this study provide further evidence that a natural specific cellular immune response against this mucin epitope exists in breast cancer patients.
Keywords
References
Document Type
ARTICLE
Publication order reference
Gabriele Pecher, Clinic of Oncology and Hematology, Charite Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
YADDA identifier
bwmeta1.element.element-from-psjc-7942dc6c-6e11-3864-95a8-d71e27797c0e
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.