PL EN


Preferences help
enabled [disable] Abstract
Number of results
2000 | 48 | 5 | 497-504
Article title

Pathogenetic mechanisms of atopic dermatitis

Title variants
Languages of publication
EN
Abstracts
EN
Atopic dermatitis (AD) is a chronic inflammatory disease which results from complex interactions between genetic and environmental mechanisms. An altered lipid composition of the stratum corneum is responsible of the xerotic aspect of the skin, and determines a higher permeability to allergens and irritants. Keratinocytes of AD patients exhibit a propensity to an exaggerated production of cytokines and chemokines, a phenomenon that can have a major role in promoting and maintaining inflammation. Specific immune responses against a variety of environmental allergens are also implicated in AD pathogenesis with a bias towards Th2 immune responses. In particular, dendritic cells expressing membrane IgE receptors, play a critical role in the amplification of allergen-specific T cell responses. Cross-linkage of specific IgE receptors on dermal mast cells provokes release and synthesis of a vast series of mediators. Following their recruitment and activation into the skin, eosinophils are also thought to contribute relevantly to tissue damage. Thus, a complex network of cytokines and chemokines contributes to establish a local milieu that favors the permanence of inflammation in AD skin.
Keywords
Publisher

Year
Volume
48
Issue
5
Pages
497-504
Physical description
Contributors
author
author
author
author
References
Document Type
REVIEW
Publication order reference
S. Pastore, Laboratory of Immunology, Istituto Dermopatico dell?Immacolata, IRCCS, Rome, Italy
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-75aa874e-42fe-3bd5-a5bb-4e636834cf77
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.