PL EN


Preferences help
enabled [disable] Abstract
Number of results
2005 | 53 | 6 | 505-517
Article title

Neutrophils in the innate immune response

Title variants
Languages of publication
EN
Abstracts
EN
Polymorphonuclear leukocytes (PMNs or neutrophils) are an essential component of the human innate immune system. Circulating neutrophils are rapidly recruited to sites of infection by host- and/or pathogen-derived components, which also prime these host cells for enhanced microbicidal activity. PMNs bind and ingest microorganisms by a process known as phagocytosis, which typically triggers production of reactive oxygen species and the fusion of cytoplasmic granules with pathogen-containing vacuoles. The combination of neutrophil reactive oxygen species and granule components is highly effective in killing most bacteria and fungi. Inasmuch as PMNs are the most abundant type of leukocyte in humans and contain an arsenal of cytotoxic compounds that are non-specific, neutrophil homeostasis must be highly regulated. To that end, constitutive PMN turnover is regulated by apoptosis, a process whereby these cells shut down and are removed safely by macrophages. Notably, apoptosis is accelerated following phagocytosis of bacteria, a process that appears important for the resolution of infection and inflammation. This review provides a general overview of the role of human neutrophils in the innate host response to infection and summarizes some of the recent advances in neutrophil biology.
Publisher

Year
Volume
53
Issue
6
Pages
505-517
Physical description
Contributors
author
author
author
author
References
Document Type
REVIEW
Publication order reference
Scott D. Kobayashi, Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-71877122-9a80-3ad8-955d-09fd95148c74
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.