Recycling of eucaryotic ribosomes

• Authors: A. Tyczewska , K. Bakowska-Zywicka
• Languages of publication: EN

Abstracts

EN

Until recently protein biosynthesis has been viewed as a process involving only three steps: initiation of translation, elongation of the nascent polypeptide chain and release of the completed unfolded polypeptide. In recent years fourth step in translation has been distinguished ? it is the recycling of the ribosome. In this process posttermination complexes termed post-TC consisting of ribosomes with deacylated tRNA(s) and mRNA are dissociated with the help of ribosome recycling factor (RRF), elongation factor G (EF-G) and initiation factor 3 (IF3) in Procaryotes. The mechanism of this final step in Eucaryotes was unknown for a long time, but the work of Pisarev et al. sheds a light on splitting 80S ribosomes and preparing them for the next cycle of translation.

Keywords

EN

RECYCLING; RIBOSOME

Discipline

• BIOTECHNOLOGY: BIOTECHNOLOGY

• Publisher: Committee of Biotechnology, Polish Academy of Sciences
• Journal: Biotechnologia
• Year: 2009
• Issue: 1
• Pages: 81-85

Contributors

author

A. Tyczewska

author

K. Bakowska-Zywicka

• Document Type: REVIEW
• Publication order reference: Agata Tyczewska, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego St. 12/14, 61-704 Pozna?, Poland