Effect of outer membrane proteins from Shigella humoral immunity induced in mice by SRBC

• Authors: Anna Czarny , Danuta Witkowska , Marian Mulczyk
• Languages of publication: EN

Abstracts

EN

Shigella flexneri outer membrane proteins (OMP) which had been earlier found to exert immunomodulatory effect on cell mediated immune response were also found to act as immunomodulator of the humoral immune response. Effects of OMP were investigated in the experiments in vitro and in vivo, where the level of humoral immune response measured as the number of plaque-forming cells (PFC) to SRBC in the spleen was evaluated. We demnostrate that small doses of OMP stimulate, whereas higher doses suppress the humoral immunity.

Keywords

EN

IMMUNITY; MEMBRANE PROTEIN; MOUSE; SHIGELLA

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 1992
• Volume: 40
• Issue: 2
• Pages: 129-134

Contributors

author

Anna Czarny

author

Danuta Witkowska

author

Marian Mulczyk

• Document Type: article