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1997 | 38 | 3 | 309-317
Article title

Molecular basis of malignant hyperthermia

Authors
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Languages of publication
EN
Abstracts
EN
Malignant hyperthermia (MH) is a clinical syndrome in which genetically susceptible individuals respond to the administration of potent inhalation anaesthetics and depolarization skeletal muscle relaxants with skeletal rigidity, unstable blood pressure, tachycardia, arrhythmias, hyperventilation, hypoxia, lactic and respiratory acidosis and high fever. In studies of the genetic basis of MH, a mutation was identified in the porcine (C1843T) and human (C1840T) skeletal muscle ryanodine receptor (RYR1) gene. This gene is mapped on human chromosome 19q13.1. The RYR1 gene contains 106 exons, of which two are alternatively spliced.
Discipline
Year
Volume
38
Issue
3
Pages
309-317
Physical description
Contributors
author
author
References
Document Type
review article
Publication order reference
P.Gronek, Department of Pig Breeding and Production, August Cieszkowski Agricultural University, Wo?ynska 33, 60-637 Poznan, Poland.
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-705551c5-81e4-3db9-98a6-e63af74851a7
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