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2006 | 54 | 6 | 367-374
Article title

Modulation of the immune response by extracellular matrix proteins

Title variants
Languages of publication
EN
Abstracts
EN
Inflammation entrains a focused and coordinated response from many different elements. Soluble factors such as chemokines and cytokines direct the recruitment, differentiation, and fate of leukocytes. Cells and pathogens are killed and consumed, yet where the response is effective, inflammation will melt away, leaving a healthy functioning tissue. All this commonly takes place in an environment known as the extracellular matrix (ECM). The ECM is not a passive partner in the process and recent work demonstrates the important role that proteins found in this environment play in connecting different parts of the immune response together. In this review we will focus on these connections and the proteins that make them. One emerging trend that we will highlight is the ability of endogenous molecules to interact with receptors that are better known as sensors of the molecular fingerprints of infection. We propose that this may be particularly relevant in the context of autoimmunity, since the provision of such signals may be crucial in breaking tolerance.
Publisher

Year
Volume
54
Issue
6
Pages
367-374
Physical description
Contributors
References
Document Type
REVIEW
Publication order reference
Lindsay B. Nicholson, School of Medical Sciences, University Walk, Bristol BS8 1TD
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-6e8b21e4-7ced-3053-8ced-dab435881659
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