Human sera with precipitating antibodies to human soluble immune complexes. A brief communication
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Previous numerous papers by the senior author dealt with the human serum factor referred to as anti-antibody which is specifically directed against IgG antibodies that underwent molecular transformation in the course of the reactions with their corresponding antigens. The reactions of this serum factor could be conveniently detected by means of agglutination of Rh-positive erythrocytes sensitized by anti Rh antibodies. No precipitation tests could be developed.Most studies were conducted by means of double diffusion in gel precipitation. Most studies were conducted by means of double diffusion in gel precipitation.Sera with precipitating anti-antibodies may serve as exquisite reagents for detection of soluble immune complexes in human sera.
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Felix Milgrom, M.D., Department of Microbiology and Immunology, State University of New York at Buffalo, 333 Sherman Hall, 3435 Main Street, Buffalo, NY 14214, USA