Nonconventional yeasts in heterologous protein production
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The purpose of the paper was to describe nonconventional yeasts: Hansenula polymorpha, Pichia pastoris, Yarrowia lipolytica, Arxula adeninivorans, Kluyveromyces lactis and Debaryomyces hansenii as affirmed or potential producers of heterologous proteins and biopharmaceutics. Cited species were characterized by genome size, particular physiological aspects and molecular tools used for genetic transformation. Advantages and disadvantages of production systems based on nonconventional yeasts were brievly discussed in comparison to well known industrial processes involving Saccharomyces cerevisiae, Escherichia coli or mammalian cells lines.
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Malgorzata Robak, Katedra Biotechnologii i Mikrobiologii Zywnosci, Wydzial Nauk o Zywnosci, Uniwersytet Przyrodniczy, ul. Norwida 25/27, 50-375 Wroclaw, Poland