The role of cytokines in experimental autoimmune encephalomyelitis

• Authors: E. Bettelli , L.B. Nicholson
• Languages of publication: EN

Abstracts

EN

Experimental autoimmune encephalomyelitis (EAE) is an animal model of the demyelinating disease multiple sclerosis. In EAE cytokines play a critical role in defining the Th1 or Th2 nature of the autoantigen directed immune response, and in propagating and regulating inflammation within the central nervous system. In this review we summarize some of the recent developments in the field of cytokine research that relate to this model of human disease, focusing principally on disease induced with the autoantigens myelin proteolipid protein and myelin oligodendrocyte protein.

Keywords

EN

AUTOIMMUNE ENCEPHALOMYELITIS; CYTOKINE; MYELIN; OLIGODENODROCYTE PROTEIN; PROTEOLIPID PROTEIN

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2000
• Volume: 48
• Issue: 5
• Pages: 389-398

Contributors

author

E. Bettelli

author

L.B. Nicholson

• Document Type: REVIEW
• Publication order reference: E. Bettelli, Center for Neurologic Diseases, Brigham and Women?s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA