Characterization of mammalian oocyte competence to undergo fertilization and embryonic development: I. Nuclear maturation and molecular aspects of its regulation
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Near the end of the growth phase, mammalian oocyte achieves competence to undergo three aspects of maturation, i.e. nuclear, cytoplasmic and genomic. All these processes are essential for the formation of an egg having the capacity for fertilization and development. This review will consider the aspects of molecular events during the process of nuclear maturation. Meiotic maturation of an oocyte is under the control of the cell cycle molecules, of which cAMP, MPF and MAP kinases seem to be the most important. The present findings regarding Ringo protein and cdc25b kinase as modulators of MPF activity and mechanism of MPF activation are discussed. Moreover, the roles of the FF-MAS, ribosomal S6 kinase p90rsk, POLO like kinases and the newly discovered proteins MISS and formin-2 are described.
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Jolanta Opiela, Zak?ad Fizjologii Rozrodu Zwierz?t, Instytut Zootechniki, 32-083 Balice