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Number of results
2002 | 50 | 4 | 263-272
Article title

The TCR/CD3 complex: molecular interactions in a changing structure

Title variants
Languages of publication
EN
Abstracts
EN
The T cell receptor-CD3 (TCR/CD3) complex is a multichain structure in charge of antigen recognition in T cells. Despite many genetic, structural, and functional data obtained in recent years, essential questions concerning the TCR/CD3 complex still remain open, including: 1) the precise number of polypeptides in each TCR/CD3 complex, their interactions and spatial arrangement; 2) the role(s) of each polypeptide in antigen recognition and/or in receptor signal transmission, and 3) the relationship between the TCR/CD3 complex and other membrane or cytoplasmic molecules involved in downstream signaling. In this work we shall review data concerning some of these issues, proposing a model of the overall structure of the TCR/CD3 complex to explain its known features.
Publisher

Year
Volume
50
Issue
4
Pages
263-272
Physical description
Contributors
author
author
author
author
author
References
Document Type
REVIEW
Publication order reference
M. J.Feito, Departmento de Inmunologia, Centro de Investigaciones Biologicas, CSIC, Madrid, Spain
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-68d7c36c-c87c-31e7-87ec-6a4e71638da7
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