The TCR/CD3 complex: molecular interactions in a changing structure

• Authors: M.J. Feito , A. Jimenez-Perianez , G. Ojeda , A. Sanchez , P. Portoles , J.M. Rojo
• Languages of publication: EN

Abstracts

EN

The T cell receptor-CD3 (TCR/CD3) complex is a multichain structure in charge of antigen recognition in T cells. Despite many genetic, structural, and functional data obtained in recent years, essential questions concerning the TCR/CD3 complex still remain open, including: 1) the precise number of polypeptides in each TCR/CD3 complex, their interactions and spatial arrangement; 2) the role(s) of each polypeptide in antigen recognition and/or in receptor signal transmission, and 3) the relationship between the TCR/CD3 complex and other membrane or cytoplasmic molecules involved in downstream signaling. In this work we shall review data concerning some of these issues, proposing a model of the overall structure of the TCR/CD3 complex to explain its known features.

Keywords

EN

ANTIGEN RECOGNITION; T CELL RECEPTOR

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2002
• Volume: 50
• Issue: 4
• Pages: 263-272

Contributors

author

M.J. Feito

author

A. Jimenez-Perianez

author

G. Ojeda

author

A. Sanchez

author

P. Portoles

author

J.M. Rojo

• Document Type: REVIEW
• Publication order reference: M. J.Feito, Departmento de Inmunologia, Centro de Investigaciones Biologicas, CSIC, Madrid, Spain