PL EN


Preferences help
enabled [disable] Abstract
Number of results
Journal
2004 | 1 | 20-31
Article title

The kidney and the bladder of transgenic animals as bioreactors?

Authors
Title variants
Languages of publication
PL
Abstracts
EN
Mammary gland-specific expression of human genes and secretion of human proteins into the milk of transgenic farm animals provides an important tool for manufacturing of many valuable pharmaceuticals. More recently, attention has focused on urine-based expression systems as a much more cost-effective technology. Successful application of this technology, however, requires the definition of several crucial regulatory elements that direct production of the protein into the urinary tract. To date, the 5? flanking region of either the uroplakin II (UPII) or uromodulin (THP) genes were used to drive the expression of heterologous proteins in the bladder or kidney epithelium of the transgenic mice, respectively. Herein, the progress and current limitations in this field are presented. Other currently known urine-specific protein genes are also described.
Publisher

Journal
Year
Issue
1
Pages
20-31
Physical description
Contributors
References
Document Type
REVIEW
Publication order reference
H.M. Zbikowska, Katedra Biochemii Ogolnej, Uniwersytet Lodzki, ul. Banacha 12/16, 90-237 Lodz, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-6868016b-0e83-3595-99ab-c68e824acac9
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.