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Journal
1996 | 4 | 153-166
Article title

Interaction of Antisense oligonucleotides with DNA and proteins studied by fluorescence polarization spectroscopy

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Languages of publication
EN
Abstracts
EN
In order to evaluate the antisense effects in biological systems, the interaction of antisense molecules with biological substances such as DNAs and human serum proteins was studied by fluorescence depolarization spectroscopy.When an antisense oligonucleotide anchoring fluorescence (F-AS) was mixed with DNAs or proteins, the anisotropy value changed, indicating that antisense oligonucleotides appreciably interact with DNAs and serum proteins, and that such interaction may play important roles on antisense gene regulation.
Publisher

Journal
Year
Issue
4
Pages
153-166
Physical description
Contributors
author
author
author
author
author
author
References
Document Type
article
Publication order reference
Akira Murakami, Dept. of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606, Japan
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-64161da9-ac8c-36e0-84c7-119d73e68ac3
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