Lack of association between Exon 1 CTLA-4 gene polymorphism A(49)G and multiple sclerosis in Polish population of the Lower Silesia Region

• Authors: D. Bocko , M. Bilinska , T. Dobosz , M. Zoledziewska , K. Suwalska , A. Tutak , E. Gruszka , I. Frydecka
• Languages of publication: EN

Abstracts

EN

Multiple sclerosis (MS) a chronic inflammatory demyelinating disease of the central nervous system (CNS) is believed to have a T-cell mediated autoimmune etiology. The cytotoxic T lymphocyte antigen 4 (CTLA-4) gene is a strong candidate for the involvement in autoimmune diseases because CTLA-4 plays an important role in downregulation of early and late stages of T cell activation and maintenance of peripheral T cell tolerance. To examine the genetic association of the CTLA-4 gene locus with MS, we analyzed exon 1 CTLA-4 gen polymorphism A(49)G in 102 unrelated Polish MS patients in Lower Silesia region and 101 age and sex matched healthy subjects. The distribution of CTLA-4 exon 1 A(49)G genotype, phenotype and allele frequencies did not differ between patients with MS and healthy subjects.

Keywords

EN

LOWER SILESIA; MULTIPLE SCLEROSIS; POLAND

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2003
• Volume: 51
• Issue: 3
• Pages: 201-205

Contributors

author

D. Bocko

author

M. Bilinska

author

T. Dobosz

author

M. Zoledziewska

author

K. Suwalska

author

A. Tutak

author

E. Gruszka

author

I. Frydecka

• Document Type: ARTICLE
• Publication order reference: D. Bocko, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland