The influence of calyculin A on lymphocytes in vitro

• Authors: A. Kowalska , M. Srebniak , A. Wawrzkiewicz , K. Kaminski
• Languages of publication: EN

Abstracts

EN

Human lymphocytes were cultured in vitro and treated with calyculin A. The aim of this work was to estimate the influence of calyculin A on chromosome morphology and banding patterns. It was also interesting whether calyculin A treatment is useful in cytogenetic analysis of human karyotype. We proved that calyculin A induces chromosome condensation in lymphocytes and raises the mitotic index significantly. Moreover, calyculin A does not influence the banding patterns. Therefore it is concluded that calyculin A can be clinically useful for human karyotyping.

Keywords

EN

CALYCULIN A; HUMAN KARYOTYPE; LYMPHOCYTE

Discipline

• GENETICS: GENETICS

• Publisher: Institute of Plant Genetics, Polish Academy of Sciences
• Journal: Journal of Applied Genetics
• Year: 2003
• Volume: 44
• Issue: 3
• Pages: 413-418

Contributors

author

A. Kowalska

author

M. Srebniak

author

A. Wawrzkiewicz

author

K. Kaminski

• Document Type: SHORT COMMUNICA
• Publication order reference: M. Srebniak, Department of Perinatology and Gynaecology, Silesian Medical Academy, Plac Traugutta 6, 41-800 Zabrze, Poland