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2003 | 57 | 4 | 405-424
Article title

The role of immunologic response in chronic allograft rejection

Authors
Title variants
Languages of publication
PL
Abstracts
EN
Chronic allograft rejection is an active immunologic and inflammatory process leading to graft failure. It is associated with many disorders evidencing increased reactivity of the host against graft alloantigens. Among the most important ones are: de novo synthesis of antibodies against HLA class I and II, immunoglobin deposits on vascular endothelial and tubular basement membrane, C4d complement deposits in peritubular capillaries, increased proliferation of lymphocytes in response to mismatched HLA-DR, and elevated expression of cytokines on infiltrating mononuclears and tubular cells. Prevention of chronic rejection comprises of transplanting undamaged organs, avoidance of acute rejection, incorporation of medicines inhibiting remodelling of vascular wall into therapy, and elimination of factors accelerating graft damage. In case of humoral chronic rejection suppression of humoral arm immune response is required. Early diagnosis and effective suppression of antibody production may allow to avoid progression of allograft failure.
Publisher

Year
Volume
57
Issue
4
Pages
405-424
Physical description
Contributors
author
References
Document Type
ARTICLE
Publication order reference
M.Boratynska, Katedra i Klinika Nefrologii i Medycyny Transplantacyjnej AM, ul. Traugutta 57/59, 50-417 Wroclaw, Poland
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YADDA identifier
bwmeta1.element.element-from-psjc-5fe60249-c790-3b55-b6fd-48d25c9114b7
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