Host immune response in B-cell lymphomas: friend or foe?

• Authors: P. Juszczynski , J. Nowak , K. Warzocha
• Languages of publication: EN

Abstracts

EN

The interaction of B-cell malignancies with the host immune system is a dynamic and bilateral process. Certain lymphomas more commonly arise against a background of autoimmunity or chronic infection. Initiation of these tumors is commonly reliant on antigenic stimulation and/or T-cell help. Apart from its tumor-fueling role, the host immune response plays a critical role in cancer immunosurveillance and immunoediting. The concept of immunoediting holds that the immune system sculpts the tumor's immunogenicity in a dynamic process that involves three essential phases: elimination, equilibrium, and escape. Data obtained by studying gene-targeted animal and human lymphomas that support the critical role of the immune response in the initiation, progression, and immunoediting of lymphoid malignancies are summarized here. A thorough understanding of this interaction will lead to the identification of more rational treatment targets and improved immunotherapies in B-cell lymphomas.

Keywords

EN

IMMUNE RESPONSE; LYMPHOMA

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2008
• Volume: 56
• Issue: 4
• Pages: 245-255

Contributors

author

P. Juszczynski

author

J. Nowak

author

K. Warzocha

• Document Type: REVIEW
• Publication order reference: Przemyslaw Juszczynski, Dana Farber Cancer Institute, Department of Medical Oncology, 44 Binney Street, Room M515, Boston, MA 02115, USA