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2008 | 56 | 4 | 245-255
Article title

Host immune response in B-cell lymphomas: friend or foe?

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Languages of publication
EN
Abstracts
EN
The interaction of B-cell malignancies with the host immune system is a dynamic and bilateral process. Certain lymphomas more commonly arise against a background of autoimmunity or chronic infection. Initiation of these tumors is commonly reliant on antigenic stimulation and/or T-cell help. Apart from its tumor-fueling role, the host immune response plays a critical role in cancer immunosurveillance and immunoediting. The concept of immunoediting holds that the immune system sculpts the tumor's immunogenicity in a dynamic process that involves three essential phases: elimination, equilibrium, and escape. Data obtained by studying gene-targeted animal and human lymphomas that support the critical role of the immune response in the initiation, progression, and immunoediting of lymphoid malignancies are summarized here. A thorough understanding of this interaction will lead to the identification of more rational treatment targets and improved immunotherapies in B-cell lymphomas.
Keywords
Publisher

Year
Volume
56
Issue
4
Pages
245-255
Physical description
Contributors
author
author
References
Document Type
REVIEW
Publication order reference
Przemyslaw Juszczynski, Dana Farber Cancer Institute, Department of Medical Oncology, 44 Binney Street, Room M515, Boston, MA 02115, USA
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-5fd2a20f-be76-3927-b958-e40f574df4fe
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