Bicuculline, AP-7 and behavioral activity in rats

• Authors: H. Car , M. Kuziemka-Leska , K. Wisniewski
• Languages of publication: EN

Abstracts

EN

The effects of bicuculline (0.25 mg/kg i.p.) and AP-7 (5 nmols icv) on the processes of retrieval, consolidation of conditioned reflexes, object recognition and locomotor activity were tested in rats. Neither AP-7, nor bicuculline nor AP-7 with bicuculline changed locomotor and exploratory activity in the open field test. Coadministration of AP-7 with bicuculline however, facilitated retrieval of passive avoidance in rats, but was without effect on consolidation in this test. Also neither AP-7 nor bicuculline when were given alone had an effect on influenced consolidation. We found no differences in effects of either AP-7 or bicuculline on object recognition regardless whether administered alone or in combination.

Keywords

EN

BICUCULLINE; LOCOMOTOR ACTIVITY; PASSIVE AVOIDANCE; RAT

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1998
• Volume: 58
• Issue: 2
• Pages: 159-164

Contributors

author

H. Car

author

M. Kuziemka-Leska

author

K. Wisniewski

• Document Type: article
• Publication order reference: H. Car, Departament of Pharmacology, Medical Academy, 2c Mickiewicz St., 15-222 Bialystok, Poland