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1998 | 58 | 2 | 159-164
Article title

Bicuculline, AP-7 and behavioral activity in rats

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Abstracts
EN
The effects of bicuculline (0.25 mg/kg i.p.) and AP-7 (5 nmols icv) on the processes of retrieval, consolidation of conditioned reflexes, object recognition and locomotor activity were tested in rats. Neither AP-7, nor bicuculline nor AP-7 with bicuculline changed locomotor and exploratory activity in the open field test. Coadministration of AP-7 with bicuculline however, facilitated retrieval of passive avoidance in rats, but was without effect on consolidation in this test. Also neither AP-7 nor bicuculline when were given alone had an effect on influenced consolidation. We found no differences in effects of either AP-7 or bicuculline on object recognition regardless whether administered alone or in combination.
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article
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H. Car, Departament of Pharmacology, Medical Academy, 2c Mickiewicz St., 15-222 Bialystok, Poland
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bwmeta1.element.element-from-psjc-5e67e6ec-e060-332a-a1d9-14c60d55734c
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