New, engineered polyketide compounds synthesized by actinomycetes

• Authors: K. Kuczek
• Languages of publication: PL

Abstracts

EN

Polyketides constitute a structurally and functionally diverse group of secondary metabolites produced by bacteria, fungi and plants. Macrocyclic polyketides are produced principally by actinomycetes using modular polyketide synthases which are giant multienzymes. These enzymes are potentially valuable for the biosynthesis of novel compounds. Engineered, hybrid polyketide synthases catalyse the formation of simple statin analogues, macrolactone ring analogues, and biologically active glycosylated compounds.

Keywords

EN

ANALOGUE   GENETIC MODIFICATION   HETEROLOGOUS EXPRESSION   MULTIPLASMID SYSTEM   POLYKETIDE   STATIN  

Discipline

• BIOTECHNOLOGY: BIOTECHNOLOGY

• Publisher: Committee of Biotechnology, Polish Academy of Sciences
• Journal: Biotechnologia
• Year: 2002
• Issue: 4
• Pages: 130-141
• Document Type: REVIEW
• Publication order reference: K. Kuczek, Zaklad Mikrobiologii, Instytut Immunologii i Terapii Doswiadczalnej im. L. Hirszfelda, Polska Akademia Nauk, ul. R. Weigla 12, 53-114 Wroclaw, Poland