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Journal
2002 | 4 | 130-141
Article title

New, engineered polyketide compounds synthesized by actinomycetes

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PL
Abstracts
EN
Polyketides constitute a structurally and functionally diverse group of secondary metabolites produced by bacteria, fungi and plants. Macrocyclic polyketides are produced principally by actinomycetes using modular polyketide synthases which are giant multienzymes. These enzymes are potentially valuable for the biosynthesis of novel compounds. Engineered, hybrid polyketide synthases catalyse the formation of simple statin analogues, macrolactone ring analogues, and biologically active glycosylated compounds.
Journal
Year
Issue
4
Pages
130-141
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References
Document Type
REVIEW
Publication order reference
K. Kuczek, Zaklad Mikrobiologii, Instytut Immunologii i Terapii Doswiadczalnej im. L. Hirszfelda, Polska Akademia Nauk, ul. R. Weigla 12, 53-114 Wroclaw, Poland
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bwmeta1.element.element-from-psjc-5e373f5f-29b2-3271-8341-a7c5e1b2b92e
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