New target against inflammatory diseases: transglutaminase 2

• Authors: S.-Y. Kim
• Languages of publication: EN

Abstracts

EN

Transglutaminase (TGase) 2 is an enzyme that is widely used in many biological systems for generic tissue stabilization or immediate defense for wounds. Many reports showed that TGase 2 is aberrantly activated in tissues and cells and contributes to a variety of diseases, including neurodegenerative diseases and autoimmune diseases. In most cases, TGase 2 appears to be a factor in the formation of inappropriate proteinaceous aggregates that may be cytotoxic. However, in other cases, such as celiac disease, arthritis, lupus, and amyotrophic lateral sclerosis, TGase 2 is involved in the generation of autoantibodies. This suggests the possibility that inappropriate expression and/or presentation of TGase 2 to T cells might contribute to these diseases in genetically predisposed individuals. We and others have found that TGase 2 expression is also increased in the inflammation process. Furthermore, we also demonstrated a reversal of inflammation by TGase inhibition. This review will examine a possibility of TGase inhibitors as therapeutic agents in a variety of inflammatory diseases.

Keywords

EN

AUTOIMMUNE DISEASE; INFLAMMATION; INHIBITOR; TRANSGLUTAMINASE

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2004
• Volume: 52
• Issue: 5
• Pages: 332-337

Contributors

author

S.-Y. Kim

• Document Type: REVIEW
• Publication order reference: Soo-Youl Kim, Department of Neurology and Neuroscience, Weill Medical College of Cornell University and Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA