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2004 | 52 | 5 | 332-337
Article title

New target against inflammatory diseases: transglutaminase 2

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EN
Abstracts
EN
Transglutaminase (TGase) 2 is an enzyme that is widely used in many biological systems for generic tissue stabilization or immediate defense for wounds. Many reports showed that TGase 2 is aberrantly activated in tissues and cells and contributes to a variety of diseases, including neurodegenerative diseases and autoimmune diseases. In most cases, TGase 2 appears to be a factor in the formation of inappropriate proteinaceous aggregates that may be cytotoxic. However, in other cases, such as celiac disease, arthritis, lupus, and amyotrophic lateral sclerosis, TGase 2 is involved in the generation of autoantibodies. This suggests the possibility that inappropriate expression and/or presentation of TGase 2 to T cells might contribute to these diseases in genetically predisposed individuals. We and others have found that TGase 2 expression is also increased in the inflammation process. Furthermore, we also demonstrated a reversal of inflammation by TGase inhibition. This review will examine a possibility of TGase inhibitors as therapeutic agents in a variety of inflammatory diseases.
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Year
Volume
52
Issue
5
Pages
332-337
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Contributors
author
References
Document Type
REVIEW
Publication order reference
Soo-Youl Kim, Department of Neurology and Neuroscience, Weill Medical College of Cornell University and Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA
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bwmeta1.element.element-from-psjc-5dbad7bc-8b7d-3ee5-868f-afa1565f728a
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