The role of genetic factors apoptosisi and 14-3-3 protein in the induction of some atopic diseases
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In this review we try to summarize some of the new informations about the genetic base of bronchial asthma. We also mention apoptosis (programmed cell death) as the process modulating cell proliferation, differentiation and death. According to the latest reports, the disorders of the regulation of apoptosis may play an important role an the pathogenesis of autoimmunologic and atopic diseases (including bronchial asthma), AIDS and neoplasmatic diseases. There is a linkage between the induction of apoptosis and signal transduction disorders. We describe the Raf/MECK/ERK/MAP signal transduction pathway and 14-3-3 protein - the peptide which possibly might participate in the initiation of the programmed cell death.
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E.Jagiello, Klinika Chorob Wewnetrznych i Alergologii AM, ul.Traugutta 57, 50-417 Wroclaw, Poland