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2009 | 69 | 2 | 177-188
Article title

The effect of alpha-tocopherol in the acute ethanol intake and its withdrawal on penicillin-induced epilepsy

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EN
The present study was designed to investigate the influence of acute ethanol intake and its withdrawal on the anticonvulsant effect of alpha-tocopherol in penicillin-induced epileptiform activity. Ethanol-treated rats received a daily dose of 3 g/kg or 9.0 g/kg of 30% ethanol solution for 3 days. Thirty minutes after penicillin injection (500 units, i.c.), the most effective dose of alpha-tocopherol (500 mg/kg) was administered intramuscularly (i.m.). Acute administration of ethanol, in a dose of 3 g/ kg, did not change either frequency or amplitude of penicillin-induced epileptiform activity, while dose of 9 g/kg ethanol significantly decreased the mean frequency of penicillin-induced epileptiform ECoG activity in the ethanol-treated group. Ethanol (9 g/kg) withdrawal also caused an increase in the amplitude of epileptiform ECoG activity in the withdrawal group. The results suggest that acute administration of high dose ethanol (9 g/kg) and alpha-tocopherol have some limited anticonvulsive effects in penicillin-induced epileptiform activity in rats.
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69
Issue
2
Pages
177-188
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ARTICLE
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Erdal Agar, Department of Physiology, Faculty of Medicine, University of Ondokuz Mayis, 55139 Samsun, Turkey
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bwmeta1.element.element-from-psjc-5ad4322d-4da2-33e5-93b2-7e7d6a740e7f
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