Selection for body weight induces differences in exploratory behavior and learning in mice

• Authors: E. Wirth-Dzieciolowska , A. Lipska , M. Wesierska
• Languages of publication: EN

Abstracts

EN

Mice that were selected for over 108 generations for body weight at the postnatal (PN) day 21 were examined in the open field (OF) test and in the Lashley maze (LM) for their exploratory behavior and spatial learning. Light (L), heavy (C) and control (K) lines of mice in three age groups: PN-21, PN-56 and PN-90, were tested once in the OF and three times in the LM. During the session in the OF the L mice displayed a steady increase of behavioral activity (sum of locomotion and rearing, climbing, sniffing, and grooming acts), whereas mice C and K habituated in the last stage. During entire session in the OF activity of the L mice was lower than that of the C and K mice. The L mice displayed high defecation/urination scores. In the learning task the L mice performed worse than the C and K mice. In conclusion, behavior of the L line was different from that of the two other lines: they showed higher anxiety and poorer spatial learning.

Keywords

EN

BODY WEIGHT   LEARNING   MICE   OPEN FIELD   SELECTION  

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2005
• Volume: 65
• Issue: 3
• Pages: 243-253
• Document Type: ARTICLE
• Publication order reference: Malgorzata Wesierska, Nencki Institute of Experimental Biology 3 Pasteur Str. 02-093 Warsaw, Poland