Diagnostic value of pancreatic elastase-1 in human acute pancreatitis

• Authors: U. Wereszczynska-Siemiatkowska , M. Jedynak , B. Mroczko , A. Siemiatkowski
• Languages of publication: EN

Abstracts

EN

The diagnosis of acute pancreatitis is usually confirmed by a significant increase of the serum amylase and/or lipase level. However, serum pancreatic elastase?1 (pEla-1) was found to be a more sensitive diagnostic marker in acute pancreatitis (AP), when assayed by RIA procedure. We analysed the serum concentration of pancreatic elastase-1, measured by ELISA technique in 46 patients with acute pancreatitis and in the control group of 12 healthy volunteers. At admission (day 1) we found significantly higher pEla-1 level in patients with AP when compared to the control group. During the following days, the concentration of pEla-1 rapidly decreased nearly to undetectable value on the third day. There was no significant difference between patients with mild and severe AP and according to aetiology. We suggest that pEla-1 has a little diagnostic value and does not provide additional information to that of cheaper and more widely available serum amylase and lipase.

Keywords

EN

ACUTE PANCREATITIS; DIAGNOSIS; PROGNOSIS

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2003
• Volume: 51
• Issue: 3
• Pages: 195-200

Contributors

author

U. Wereszczynska-Siemiatkowska

author

M. Jedynak

author

B. Mroczko

author

A. Siemiatkowski

• Document Type: ARTICLE
• Publication order reference: U. Wereszczynska-Siemiatkowska, Department of Gastroenterology, Medical University, Bialystok, Poland