Imidazoline receptor antagonists - new perspectives in the traetment of hypertension

• Authors: M. Nowicki , A. Wiecek , J. Chudek
• Languages of publication: PL

Abstracts

EN

Adrenrgic alpha2-receptors mediate important regulatory functions in both the brain and the periphery. Activation of these receptors lowers blood pressure through a decrease in sympathetic and vasomotor nerve activity.Agonists of the alpha2-adrenoreceptors are often used in the treatment of arterial hypertension.As recently discovered, their chemical structure includes so called "imidazoline ring" and compounds with such chemical structure bind to nonadrenergic sites known as imidazoline receptors.These receptors are localized in midportions of the brain by they also present in otherorgans such a lungs, heart, adrenal medulla, liver and kidneys.Their selective activation lowers blood pressure without inducing sedation typical for alpha2-agonists.Several substances binding with high selectivity to imidazoline receptors have recently been synthetized.Some of them as rilmenidine and moxonidine have successfully been introduced to the treatment of arterial hypertension in humans.

Keywords

EN

HIPERTENSION TREATMENT; IMIDAZOLINE RECEPTOR ANTAGONIST

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 1995
• Volume: 49
• Issue: 5
• Pages: 631-643

Contributors

author

M. Nowicki

author

A. Wiecek

author

J. Chudek

• Document Type: article
• Publication order reference: M.Nowicki