Effect of granulocyte-macrophage colony stimulating growth factor on interferon and tumor necrosis factor production in whole blood cell cultures of patients with acute myelogenous leukemia

• Authors: T. Kaminska , I. Hus , A. Dmoszynska , M. Kandefer-Szerszen
• Languages of publication: EN

Abstracts

EN

The effect of recombinant human granulocyte-macrophage colony-stimulating growth factor (rHuGM-CSF) treatement on in vitro interferon (IFN) and tumor necrosis factor (TNF) production in peripheral blood cells of 46 patients with acute myelogenous leukemia (AML) was examined. GM-CSF significant enhanced virus-induced IFN- production in blood cells (containing 70% of blasts) of 28 patients with M4-M5 AML according to the French-American-British (FAB) classification and also phytohemagglutinin (PHA)-induced IFN- production in blood cells (containing 68% of blasts) of 18 patients with AML M0-M3 type. In control blood cells (25 healthy persons) GM-CSF enhanced PHA-induced IFN- but did not influence IFN- production. In the presence of GM-CSF, TNF- titers induced with lipopolysaccharide were also higher in control blood cells but not in cells of patients with M0-M3 or M4-M5 type of AML. The significance of GM-CSF-enhanced IFN- and IFN- production in antimicrobial and antileukemic immune reactions which can develop during GM-CSF therapy is discussed.

Keywords

EN

ACUTE MYELOGENOUS LEUKEMIA; INTERFERON; TUMOR NECROSIS FACTOR

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2001
• Volume: 49
• Issue: 2 suppl.
• Pages: 83-88

Contributors

author

T. Kaminska

author

I. Hus

author

A. Dmoszynska

author

M. Kandefer-Szerszen

• Document Type: ARTICLE
• Publication order reference: T. Kaminska, Department of Virology and Immunology, Institute of Microbiology and Biotechnology, Maria Curie-Sk?odowska University, Akademicka 19, 20-033 Lublin, Poland,