Direct effects of lithium chloride on the activities of D5-3b and 17b-hydroxysteroid dehydrogenase in the testis and Bidder?s organ of the adult toad (Bufo melanostictus) ? in vitro study

• Authors: D. K. Nandi , J. M. Debnath , D. Ghosh
• Languages of publication: EN

Abstracts

EN

Steroidogenic key enzymes, i.e. D5-3b and 17b-hydroxysteroid dehydrogenase (D5-3b and 17b-HSD) activities, in the testis and Bidder?s organ of the toad were inhibited and ascorbic acid synthesis in these organs was decreased by a wide range of lithium concentrtion in in vitro study. A significant inhibition was noted at a concentration of 2.0 mM, which is easily achieved in the blood during the treatment of manic patients by lithium chloride. This experiment reflected that lithium exerts a direct inhibitory effect on hydroxysteroid dehydrogenase activities in the testis and Bidder?s organ ? a rudimentary ovary in Bufo.

Keywords

EN

ASCORBIC ACID; BIDDER?S ORGAN; BIDDER?S ORGAN; LITHIUM; TESTIS

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Institute of Systematics and Evolution of Animals, Polish Academy of Sciences
• Journal: Folia Biologica
• Year: 1999
• Volume: 47
• Issue: 3-4
• Pages: 73-76

Contributors

author

D. K. Nandi

author

J. M. Debnath

author

D. Ghosh

• Document Type: ARTICLE
• Publication order reference: D. K. Nandi, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore ? 721 102, West Bengal, India, and Department of Physiology, Raja Narendralal Khan Women?s College, Midnapore ? 721 102, W.B., India