PL EN


Preferences help
enabled [disable] Abstract
Number of results
2006 | 54 | 2 | 103-111
Article title

The distinctive role of small heat shock proteins in oncogenesis

Title variants
Languages of publication
EN
Abstracts
EN
Recently, the role of small heat shock proteins (HSPs) has been widely recognized in cancer research. Small HSPs are tumor-protective via numerous, independent mechanisms such as: oxidative stress protection preventing protein denaturation, anti-apoptotic activity, and likely direct suppression of the immune system. However, it is unclear whether they play any role in the initial steps in carcinogenesis. This article seeks to familiarize the reader with general characteristics of small HSPs (especially HSP-27, A/B-crystallins), tissue distribution with special regard on their expression in malignant specimens, and biological properties of intracellular HSP-27 and A/B-crystallins promoting tumor genesis and growth. A separate chapter describes immunomodulatory characteristics of extracellular HSP-27 with special emphasis on their plausible effect on the neoplasm development.
Publisher

Year
Volume
54
Issue
2
Pages
103-111
Physical description
Contributors
References
Document Type
REVIEW
Publication order reference
Krzysztof Laudanski, Department of Medicine, Griffin Hospital, 130 Division St., Derby, CT 06418, USA
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-4e4711d5-7584-3503-9f76-1a726513e5f1
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.