The distinctive role of small heat shock proteins in oncogenesis

• Authors: K. Laudanski , D. Wyczechowska
• Languages of publication: EN

Abstracts

EN

Recently, the role of small heat shock proteins (HSPs) has been widely recognized in cancer research. Small HSPs are tumor-protective via numerous, independent mechanisms such as: oxidative stress protection preventing protein denaturation, anti-apoptotic activity, and likely direct suppression of the immune system. However, it is unclear whether they play any role in the initial steps in carcinogenesis. This article seeks to familiarize the reader with general characteristics of small HSPs (especially HSP-27, A/B-crystallins), tissue distribution with special regard on their expression in malignant specimens, and biological properties of intracellular HSP-27 and A/B-crystallins promoting tumor genesis and growth. A separate chapter describes immunomodulatory characteristics of extracellular HSP-27 with special emphasis on their plausible effect on the neoplasm development.

Keywords

EN

A-CRYSTALLIN; B-CRYSTALLIN; CARCINOGENESIS; IMMUNE SYSTEM; NEOPLASM; SMALL HEAT SHOCK PROTEIN

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2006
• Volume: 54
• Issue: 2
• Pages: 103-111

Contributors

author

K. Laudanski

author

D. Wyczechowska

• Document Type: REVIEW
• Publication order reference: Krzysztof Laudanski, Department of Medicine, Griffin Hospital, 130 Division St., Derby, CT 06418, USA