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Number of results
2001 | 49 | 4 | 293-302
Article title

Cytokine-based immunotherapy of allergic disease

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Languages of publication
EN
Abstracts
EN
Human immediate hypersensitivity diseases are strongly associated with an excessive type 2 response to normally innocuous environmental antigens, and are a growing health care concern in developed nations. Commonly prescribed treatments provide effective symptomatic relief, but are unable to consistently ameliorate the underlying cause of allergic disease: the excessive generation of allergen specific Th2 cells. IL-12 and IL-18 are potent inducers of type 1 immunity, and, as such, have been proposed as candidates for treatment of allergic diseases. This review critically assesses the potential of recombinant IL-12 and IL-18 immunotherapy to redirect both de novo and established allergic responses in animal models of human allergic disease to clinically protective immune responses.
References
Document Type
REVIEW
Publication order reference
I. P. Lewkowich, Department of Immunology, University of Manitoba, Winnipeg, Canada
YADDA identifier
bwmeta1.element.element-from-psjc-4dabcd9d-a734-383c-9c31-53dd89692308
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