PL EN


Preferences help
enabled [disable] Abstract
Number of results
2005 | 53 | 6 | 518-527
Article title

The biological role and potential therapeutic application of interleukin 7

Title variants
Languages of publication
EN
Abstracts
EN
Interleukin 7 (IL)-7 is a pleiotropic, non-redundant cytokine necessary for the development of B and T lymphocytes, in particular gamma delta T cell receptor-positive cell differentiation. The cytokine can function as a cofactor during myelopoiesis and the generation of cytotoxic T cells and natural killer cells, can activate monocytes/macrophages, and support the survival of mature T cells. A role for IL-7 in promoting the formation of Peyer's patch anlage has also been demonstrated. IL-7 is constitutively expressed in the thymus, bone marrow stromal cells, epithelial and dendritic cells, keratinocytes, as well as in fetal and adult liver. IL-7 acts on various cells through its receptor (IL-7R), a heterodimer consisting of an alpha chain (CD127) that specifically binds IL-7 and a common c chain (CD132) shared by other cytokine receptors. The receptor is expressed on bone marrow progenitor cells, lymphoid T and B precursors, and mature T cells. IL-7 activity towards murine endothelial cells has been recently described. The presence of IL-7R on human endothelial cells has also been demonstrated. Several therapeutic applications of recombinant IL-7 have been proposed. These have focused on the enhancement of lymphopoiesis, promotion of stem cell engraftment, and the anti-tumor activity of the cytokine.
Keywords
Publisher

Year
Volume
53
Issue
6
Pages
518-527
Physical description
Contributors
author
author
author
References
Document Type
REVIEW
Publication order reference
Agnieszka Krawczenko, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-4b2ed354-a76d-3321-82e8-9a328b816b6f
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.