Sjogren's syndrome: An old tale with a new twist

• Authors: B.H. Lee , M.A. Tudares , C.Q. Nguyen
• Languages of publication: EN

Abstracts

EN

Sjogren's syndrome (SjS) is chronic autoimmune disease manifested by the loss of saliva and/or tear secretion by salivary and/or lacrimal glands, respectively. The pathogenesis of the disease remains elusive, perhaps due to the multiple triggers of the disease. However, substantial advances have been made in attempting to resolve the complexity of SjS using both animal models and human subjects. The primary objectives of this review are to provide a better understanding of the disease processes with major emphasis on the use of mouse models, how genetic predisposition plays a role in the natural history of the disease, as well as a presentation of new findings pertaining to the role of TH1, TH2, and TH17 cells in the pathogenesis of SjS.

Keywords

EN

ANIMAL MODEL; GENETICS; SJOGREN SYNDROME; TH1 CELL; TH17 CELL; TH2 CELL

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2009
• Volume: 59
• Issue: 1
• Pages: 57-66

Contributors

author

B.H. Lee

author

M.A. Tudares

author

C.Q. Nguyen

• Document Type: REVIEW
• Publication order reference: Cuong Q. Nguyen, PhD, Department of Oral Biology, PO Box 100424, College of Dentistry, University of Florida, Gainesville, FL 32610, USA