Modulation of radiation-induced biochemical changes in cerebrum of Swiss albino mice by Grewia asiatica
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The present study evaluates the possible radioprotective effect of Grewia asiatica fruit (rich in anthocyanin, carotenes, vitamin C, etc.) pulp extract (GAE) on cerebrum of Swiss albino mice exposed to 5 Gy gamma radiation. For this, healthy mice from an inbred colony were divided into four groups: (1) Control (vehicle treated), (2) GAE treated ? mice in this group were orally supplemented with GAE (700 mg/kg. b.w. /day) once daily for fifteen consecutive days, (3) Vehicle treated irradiated mice, and (4) GAE + Irradiated ? Mice in this group received distilled water orally equivalent to GAE (700 mg/kg. b.w./day) for fifteen days consecutively. Mice were sacrificed at various intervals viz. 1?30 days. Radiation-induced augmentation in the levels of lipid peroxidation of mice cerebrum was significantly ameliorated by GAE pretreatment. Radiation-induced depletion in the level of glutathione and protein was prevented significantly by GAE administration.
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R. Sisodia, Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, 302004 India