Protease inhibitors from fungi as potential pharmaceuticals
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For last several years, proteases have been firmly established as main regulatory components in a number of cellular, tissue and physiological processes. The most important factors influencing the proteases are natural protease inhibitors which form complexes with target proteases to inactivate and/or to regulate their activity. They have been investigated from the points of view of physiological functions, tools for analysing protease enzymology, models for protein-protein and protease-protein interactions, and on medical applications. There is growing interest in new inhibitors of proteases not only synthetic, but also naturally occurring (mushroom ones among them), due to their role in various human diseases.
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Krzysztof Grzywnowicz, Zak?ad Biochemii, Uniwersytet Marii Curie-Sk?odowskiej, pl. Marii Curie-Sk?odowskiej 3, 20-031 Lublin, Poland