Electrophysiological studies on adaptive changes of serotonin receptors using spontaneous epileptiform activity in neuronal network

• Authors: B. Bobula , A. Zahorodna , K. Tokarski , G. Hess
• Languages of publication: PL

Abstracts

EN

Certain antidepressant medications exert effects on the serotonergic (5-HT) syste but their machanisms are still not well understood. Using extracellular ex vivo recording of spontaneous, epileptiform activity of neurons we determined changes in the reactivity of cortical and hippocampal slices to agonists of main subtypes 5-HT receptors, induced by repeated administration of the antidepressants . Repeated treatment with antidepressants enhances the 5-HT-mediated inhibition in both frontal cortex and hippocampal regions. Drugs administration induce opposite adaptive changes within 5-HT2 and 5-HT1A receptors in frontal cortex as well as in 5-HT1A and 5-HT4 receptors in the hippocampus. These effects may contribute to therapeutic effects of antidepressants administration.

Keywords

EN

ADAPTIVE CHANGE   SEROTONIN RECEPTOR  

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Index Copernicus International; Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 2002
• Volume: 56
• Issue: 3
• Pages: 377-383
• Document Type: ARTICLE
• Publication order reference: B. Bobula, Instytut Farmakologii PAN, ul. Smetna 12, 31-343 Krakow, Poland