PL EN


Preferences help
enabled [disable] Abstract
Number of results
2002 | 56 | 3 | 377-383
Article title

Electrophysiological studies on adaptive changes of serotonin receptors using spontaneous epileptiform activity in neuronal network

Content
Title variants
Languages of publication
PL
Abstracts
EN
Certain antidepressant medications exert effects on the serotonergic (5-HT) syste but their machanisms are still not well understood. Using extracellular ex vivo recording of spontaneous, epileptiform activity of neurons we determined changes in the reactivity of cortical and hippocampal slices to agonists of main subtypes 5-HT receptors, induced by repeated administration of the antidepressants . Repeated treatment with antidepressants enhances the 5-HT-mediated inhibition in both frontal cortex and hippocampal regions. Drugs administration induce opposite adaptive changes within 5-HT2 and 5-HT1A receptors in frontal cortex as well as in 5-HT1A and 5-HT4 receptors in the hippocampus. These effects may contribute to therapeutic effects of antidepressants administration.
References
Document Type
ARTICLE
Publication order reference
B. Bobula, Instytut Farmakologii PAN, ul. Smetna 12, 31-343 Krakow, Poland
YADDA identifier
bwmeta1.element.element-from-psjc-484f8d30-e837-3009-a2d3-7516f19cbb8c
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.