Nucleic acid aptamers in human viral disease

• Authors: Z. Zhang , M. Blank , H.J. Schluesener
• Languages of publication: EN

Abstracts

EN

Nucleic acid aptamers are short, single-stranded oligonucleotides or their modified analogues which avidly and specifically interact with targeted ligands through their 3-dimensional structure. Aptamers can be selected out of a large combinatorial oligonucleotide library through an in vitro evolution process termed SELEX. Since 1990, a wide variety of aptamers targeted to ligands ranging from small molecules to complex mixtures have been isolated. Most selected aptamers have shown high specificity to and affinity for their ligands and are potential detection and/or diagnostic reagents. Furthermore, some aptamers specifically inhibit biological functions of targeted proteins, resulting in potent therapeutic candidates in disease models. Some recent advances to increase the stability of aptamers, extend their in vivo circulation time and their in vivo expression have pushed aptamers closer to therapeutic applications. This review presents recent developments in the field of aptamer research and focuses on their applications to human viral diseases, particularly HIV induced diseases.

Keywords

EN

HUMAN VIRAL DISEASE; NUCLEIC ACID APTAMER; THERAPEUTIC APPLICATION

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2004
• Volume: 52
• Issue: 5
• Pages: 307-315

Contributors

author

Z. Zhang

author

M. Blank

author

H.J. Schluesener

• Document Type: REVIEW
• Publication order reference: Zhiren Zhang, Institute of Brain Research, University of Tuebingen, Calwer Str. 3, D-72076 Tuebingen, Germany