EN
Experimental aortic aneurysm may be evoked in animals by application of chemical compounds disturbing biosynthesis, posttranlating modifications and degradation of elastin and collagen, local damage of the aortic wall by chemical, thermal and mechanical factors and by increased blood preasure. Administration of protease inhibitors, anti-inflammatory drugs, agents enhancing synthesis and formation of elastic and collagen fibers and hypotensive drugs prevent formation enlargment and rupture of aneurysm.