PL EN


Preferences help
enabled [disable] Abstract
Number of results
Journal
1994 | 4 | 50-54
Article title

Stability of antisense oligonucleotides - the possibillities of their enzymatic digestion

Content
Title variants
Languages of publication
PL
Abstracts
EN
Nucleotic enzymes (5- and 3-nucleases, exo and endonucleases) can degrede short unmodified oligonucleotides applied as potential antisense agents. Better stability of oligonucleotides against nucleolytic enzymes can be achieved by chemical modification of internucleotide bonds.Stability of the phosphorothioate, phosphoroditioate and methylphosphonate analogues of oligonucleotides against nuclease P1,3-exonuclease, snake venom phosphodiesterase and other nucleases is discussed
Journal
Year
Issue
4
Pages
50-54
Physical description
References
Document Type
article
Publication order reference
M.Koziolkiewicz
YADDA identifier
bwmeta1.element.element-from-psjc-47995afd-87ad-388e-bf64-4c3dd2e65f17
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.