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Abstracts
Nucleotic enzymes (5- and 3-nucleases, exo and endonucleases) can degrede short unmodified oligonucleotides applied as potential antisense agents. Better stability of oligonucleotides against nucleolytic enzymes can be achieved by chemical modification of internucleotide bonds.Stability of the phosphorothioate, phosphoroditioate and methylphosphonate analogues of oligonucleotides against nuclease P1,3-exonuclease, snake venom phosphodiesterase and other nucleases is discussed
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Journal
Year
Issue
Pages
50-54
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author
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Document Type
article
Publication order reference
M.Koziolkiewicz
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YADDA identifier
bwmeta1.element.element-from-psjc-47995afd-87ad-388e-bf64-4c3dd2e65f17