MHC class II positive microglia and lymphocytic infiltration are present in the substantia nigra and striatum in mouse model of Parkinson's disease

• Authors: I. Kurkowska-Jastrzebska , A. Wronska , M. Kohutnicka , A. Czlonkowski , A. Czlonkowska

Abstracts

EN

We have studied MHC class II antigen expression and lymphocytic infiltration during dopaminergic neurone degeneration produced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropiridine (MPTP). Microglial activation was observed in the striatum and in the substantia nigra (SN) in this model. We noticed a marked increase of MHC class II antigen expression on microglia and T-cell recruitment in these regions after MPTP treatment. B-lymphocytes were not observed. T-cell infiltration predominantly consisted of CD8+ cells at every time point but CD4+ cells were present too. More than a half of the observed lymphocytes showed strong staining of CD44 antigen. Our findings suggest a possible immune system involvement in the pathological process following MPTP intoxication.

Keywords

EN

MICROGLIA; NEURODEGENERATION

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1999
• Volume: 59
• Issue: 1
• Pages: 1-8

Contributors

author

I. Kurkowska-Jastrzebska

author

A. Wronska

author

M. Kohutnicka

author

A. Czlonkowski

author

A. Czlonkowska

• Publication order reference: A. Czlonkowska, Department of Pharmacology, Medical Academy of Warsaw, 26 Krakowskie Przedmiescie St., 00-927 Warsaw, Poland