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Journal
2003 | 51 | 3-4 | 195-199
Article title

Effects of phenylhydrazine or recombinant human erythropoietin on deformability and activity of dehydrogenase glucose-6-phosphate and acetylcholinesterase in Wistar rats blood enriched in reticulocytes

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Abstracts
EN
Deformability and activity of the enzymes: acetylcholinesterase (AChE) and dehydrogenase glucose-6-phosphate (G-6-PD), were assayed for RBC enriched in immature reticulocytes. Reticulocytosis was evoked by administration of two different drugs: recombinant human erythropoietin (rHuEPO) and phenylhydrazine (PHZ) to two groups of Wistar rats. After treatment with the former compound, a group of animals exhibited 17,33 % reticulocytes in blood whereas a group of rats treated with the latter drug reached 57,66 % of these cells in blood. A marked decrease in RBC deformability was found in both groups of animals. AChE did not significantly change activity neither in PHZ-treated nor in rHuEPO-treated rats, whereas G-6-PD activity was significantly decreased in the PHZ-treated group.
References
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ARTICLE
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Z. Dabrowski, Department of Hematology and Toxicology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30-060 Krakow, Poland
YADDA identifier
bwmeta1.element.element-from-psjc-475676cc-b11f-36d7-9822-0cc6b264b2e2
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