Promoting phorbol ester-TPA enhances migration of C3H 10TI/2ells.The role of protein kinase C and its relation to carcinogenesis

• Authors: P. Janik , B. Szaniawska , D. Kowalczyk , K. Maternicka
• Languages of publication: EN

Abstracts

EN

Treatment of 10T1/2 cells with promoting phorbol ester drasticly enhanced migration studied fibroblasts in a serum-supplemented medium.The same cells when exposed to ionomycin or TPA in a serum-free medium did not show any migration.The addition of 1% of serum induced spontaneous and TPA stimulated migration.Also EGF and PDGE separatly or together induced the migration of 10T1/2 cells.Parallel studies of protein kinase C documented low enzymatic activity after treatment with TPA, whereas transcripts of PKC were shown independently of TPA treatment.

Keywords

EN

CELL MIGRATION; PHORBOL ESTER; PROTEIN KINASE C

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Institute of Systematics and Evolution of Animals, Polish Academy of Sciences
• Journal: Folia Biologica
• Year: 1995
• Volume: 43
• Issue: 3-4
• Pages: 83-87

Contributors

author

P. Janik

author

B. Szaniawska

author

D. Kowalczyk

author

K. Maternicka

• Document Type: article
• Publication order reference: P.Janik