From sequence to function ? looking for genes and their annotations

• Authors: K. Baczkowski , P. Mackiewicz , M. Kowalczuk , J. Banaszak , S. Cebrat
• Languages of publication: EN

Abstracts

EN

Today, we have very powerful and effective machines and methods to sequence and analyze DNA sequences. Almost every week, new genomes are added to sequence databases. However, those data are useless without additional annotations. Genes need to be found and their functions defined. Experimental work is too slow to analyze each sequence of a potential gene but computational methods facilitate such analyses. Here, we review the methodology, potential problems and constraints in genes finding and their annotation. We describe some new approaches including comparative genomics.

Keywords

EN

GENE FUNCTION; GENOME; GENOMICS

Discipline

• BIOTECHNOLOGY: BIOTECHNOLOGY

• Publisher: Committee of Biotechnology, Polish Academy of Sciences
• Journal: Biotechnologia
• Year: 2005
• Issue: 3
• Pages: 22-44

Contributors

author

K. Baczkowski

author

P. Mackiewicz

author

M. Kowalczuk

author

J. Banaszak

author

S. Cebrat

• Document Type: REVIEW
• Publication order reference: Krystian Baczkowski, Zaklad Genomiki, Instytut Genetyki i Mikrobiologii, Uniwersytet Wroclawski, ul. Przybyszewskiego 63/77, 51-148 Wroclaw, Poland