Is there any mystery of ORPHANs ?

• Authors: S. Cebrat , M. Dudek , P. Mackiewicz
• Languages of publication: EN

Abstracts

EN

We have analysed the coding capacity of ORFs longer than 100 codons found in the yeast genome. Comparing the parameters describing the DNA asymmetry in the set of known genes and the set of all ORFs>100 codons we have found that there are about 4700 coding ORFs in the yeast genome. Since for more than 2300 ORFs recognisable functions have been already found and for about 2000 ORFs homology to known genes has been identified - only about 400 ORFs can be considered as orphans - ORFs without any known function or homology. This finding means that there is no mystery of orphans - a paradox showing that the fraction of orphans has been growing with the growing number of genes with known functions in the yeast genome.

Keywords

EN

CODING ORF; DNA ASYMMETRY; GENE FINDING; GENE NUMBER; ORPHAN; SACCHAROMYCES CEREVISIAE

Discipline

• GENETICS: GENETICS

• Publisher: Institute of Plant Genetics, Polish Academy of Sciences
• Journal: Journal of Applied Genetics
• Year: 1997
• Volume: 38
• Issue: 4
• Pages: 365-372

Contributors

author

S. Cebrat

author

M. Dudek

author

P. Mackiewicz

• Document Type: article
• Publication order reference: S.Cebrat, Institute of Microbiology, Wroclaw University, Wroclaw, Poland