Antibodies and drug-carriers in targeted therapy - progress and limitations
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The paper addresses the problems of carriers and antibodies in targeted therapy. Also the new material of liquid crystalline nature, designed for use as a drug vehicle in the immune targeting technique is presented and its property is discussed. Obtained by self-assembling, the ribbon-like supramolecular organisation products of some azo-dyes, particularly including Congo red and Evans blue, form micellar bodies of this carrier. They bind spontaneously and selectively to immune complexes but not to free antibodies. The binding strongly enhances the antigen - antibody interaction. Micelles of the carrier composed of self-assembled molecules easily incorporate many foreign substances including drugs, favouring however those of possibly planar molecules. The excess of carrier leaves the organism rapidly through the urine tract, reducing the possible side effects. The nature of chromonic liquid crystalline material is suitable for many modifications and adapting elaboration.
Publication order reference
L. Konieczny, Instytut Biochemii Lekarskiej, Collegium Medicum, Uniwersytet Jagiellonski, ul. Kopernika 7, 31-034 Krakow, Poland