PL EN


Preferences help
enabled [disable] Abstract
Number of results
2001 | 61 | 1 | 21-26
Article title

Lipid metabolism parameters in patients with Alzheimer disease and their first degree relatives

Content
Title variants
Languages of publication
EN
Abstracts
EN
Recently, it was suggested that the presence of total cholesterol (TC), age and sex interaction in Alzheimers type dementia (AD) is linked with the apolipoprotein E (APOE) genotype. Our objective was to determine whether the serum lipid profile in AD patients and their first degree non-demented relatives of a certain age (NDR) was dependent on APOE genotype. We included 28 mild to moderate AD and 30 NDR according to DSM-III-R and NINCDS-ADRDA criteria. NDR individuals were investigated in an age group similar to the AD group (brother-sister relationship) and in a group including younger individuals (AD patients-children relationship). Our data indicate significant differences between decreased total cholesterol and low density lipoprotein cholesterol ratio in the group of AD patients versus NDR individuals of similar age, independent of APOE genotype, and an increased total cholesterol and low density lipoprotein cholesterol ratio in a group of AD patients versus their children of the same genotype. There was no significant correlation between triglycerides and high density lipoprotein levels with APOE genotype in any of the tested groups. In conclusion, there was a decreased selected lipid serum profile parameters in AD compared to age matched non demented first degree relatives.
References
Document Type
article
Publication order reference
YADDA identifier
bwmeta1.element.element-from-psjc-403b1736-d621-3f3a-a39a-f1474575b285
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.