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2002 | 50 | 2 | 121-130
Article title

GM-CSF regulation in eosinophils

Title variants
Languages of publication
EN
Abstracts
EN
Allergic asthma is characterized by a temporally and quantitatively inappropriate immunologic response. One of hallmarks of this response is the accumulation of eosinophils in the airway and lung parenchyma, which results in bronco-constriction, lung damage and ultimately fibrosis. GM-CSF plays a pivotal role in this process by modulating eosinophil function and survival. In this review, we discuss the effects and molecular regulation of GM-CSF secretion by eosinophils. Recent data demonstrate activated eosinophils release small amounts of anti-apoptotic GM-CSF by stabilizing its coding mRNA.
Keywords
EN
Publisher

Year
Volume
50
Issue
2
Pages
121-130
Physical description
Contributors
author
author
References
Document Type
REVIEW
Publication order reference
S.Esnault, Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-402e7e0b-75b8-34bf-be24-f09c61739df9
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