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2002 | 50 | 2 | 121-130
Article title

GM-CSF regulation in eosinophils

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Languages of publication
EN
Abstracts
EN
Allergic asthma is characterized by a temporally and quantitatively inappropriate immunologic response. One of hallmarks of this response is the accumulation of eosinophils in the airway and lung parenchyma, which results in bronco-constriction, lung damage and ultimately fibrosis. GM-CSF plays a pivotal role in this process by modulating eosinophil function and survival. In this review, we discuss the effects and molecular regulation of GM-CSF secretion by eosinophils. Recent data demonstrate activated eosinophils release small amounts of anti-apoptotic GM-CSF by stabilizing its coding mRNA.
Keywords
EN
Contributors
author
author
References
Document Type
REVIEW
Publication order reference
S.Esnault, Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-402e7e0b-75b8-34bf-be24-f09c61739df9
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