GM-CSF regulation in eosinophils

• Authors: S. Esnault , J.S. Malter
• Languages of publication: EN

Abstracts

EN

Allergic asthma is characterized by a temporally and quantitatively inappropriate immunologic response. One of hallmarks of this response is the accumulation of eosinophils in the airway and lung parenchyma, which results in bronco-constriction, lung damage and ultimately fibrosis. GM-CSF plays a pivotal role in this process by modulating eosinophil function and survival. In this review, we discuss the effects and molecular regulation of GM-CSF secretion by eosinophils. Recent data demonstrate activated eosinophils release small amounts of anti-apoptotic GM-CSF by stabilizing its coding mRNA.

Keywords

EN

ASTHMA; EOSINOPHIL; MRNA; SURVIVAL

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2002
• Volume: 50
• Issue: 2
• Pages: 121-130

Contributors

author

S. Esnault

author

J.S. Malter

• Document Type: REVIEW
• Publication order reference: S.Esnault, Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA