PL EN


Preferences help
enabled [disable] Abstract
Number of results
2004 | 64 | 1 | 89-98
Article title

The role of metabotropic glutamate receptors in Alzheimer's disease

Content
Title variants
Languages of publication
EN
Abstracts
EN
While glutamatergic transmission is severely altered by early degeneration of cortico-cortical connections and hippocampal projections in Alzheimer's disease (AD), the role of glutamate receptors in the pathogenesis of AD is not yet defined clearly. Nonetheless, as reviewed here, the topographical distribution of different types of receptors likely contributes to the regional selective nature of neuronal degeneration. In particular, metabotropic glutamate receptors (mGluR) may contribute the pathogenesis of many neurological conditions and also regulate neuronal vulnerability against cytotoxic stress. Thus, we here discuss the possible role of mGluR in the pathogenesis of AD based on the results from other neurodegenerative diseases that may give us clues to solve the mysterious selective neurodegeneration evident in AD.
Keywords
References
Document Type
REVIEW
Publication order reference
M.A. Smith, Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 4106, USA
YADDA identifier
bwmeta1.element.element-from-psjc-3e7338aa-d7fe-39fb-be0d-10bf8a00c863
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.